Shows Vaccine Will Enhance Delta Infectivity
August 30, 2021 (1)
Japanese researchers have submitted a new study showing that mRNA
vaccines may actually enhance the infectivity of the Delta variant,
making it completely resistant to the vaccine.
While the vaccines have shown to be effective against certain variants
of concern (VOC), there is a “tradeoff “ that the same antibodies that
offer vaccine-induced immunity make to also fuel growth of
vaccine-resistant mutations, the researchers found. Specifically, these
same antibodies can also “enhance the infectivity of SARS-CoV-2 by
inducing the open form of the RBD (receptor binding domain).”
The researchers’ study examined the neutralizing and enhancing
functions of these antibodies and found “an evolutionary pathway by
which the Delta variant could achieve complete escape from
vaccine-induced immunity, which provides important information for the
design of next-generation vaccines.”
This information matters when making predictions for future mutations
of the Delta variant, the researchers said, as “these results suggest
that the Delta variant may acquire full resistance to BNT162b2 immune
sera by acquiring additional mutations in the RBD that disrupt
recognition of anti-RBD neutralizing antibodies.”
Report, 30-Aug-2021 (only available in the original site for 48
hours after publication date)
(2) References as quoted in the
original News Report page:
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